| Date | Time | Away Team | Home Team | |
|---|---|---|---|---|
| Oct. 6, 2011 | 10 p.m. | Pittsburgh Penguins | @ | Vancouver Canucks |
| Oct. 8, 2011 | 10 p.m. | Pittsburgh Penguins | @ | Calgary Flames |
| Oct. 9, 2011 | 9 p.m. | Pittsburgh Penguins | @ | Edmonton Oilers |
| Oct. 11, 2011 | 7:30 p.m. | Florida Panthers | @ | Pittsburgh Penguins |
| Oct. 13, 2011 | 7 p.m. | Washington Capitals | @ | Pittsburgh Penguins |
| Oct. 15, 2011 | 7 p.m. | Buffalo Sabres | @ | Pittsburgh Penguins |
| Oct. 17, 2011 | 8:30 p.m. | Pittsburgh Penguins | @ | Winnipeg Jets |
| Oct. 18, 2011 | 7:30 p.m. | Pittsburgh Penguins | @ | Minnesota Wild |
| Oct. 20, 2011 | 7 p.m. | Montreal Canadiens | @ | Pittsburgh Penguins |
| Oct. 22, 2011 | 7 p.m. | New Jersey Devils | @ | Pittsburgh Penguins |
| Oct. 25, 2011 | 7 p.m. | Pittsburgh Penguins | @ | New York Islanders |
| Oct. 27, 2011 | 7 p.m. | New York Islanders | @ | Pittsburgh Penguins |
| Oct. 29, 2011 | 7 p.m. | Pittsburgh Penguins | @ | Toronto Maple Leafs |
| Nov. 3, 2011 | 10:30 p.m. | Pittsburgh Penguins | @ | San Jose Sharks |
| Nov. 5, 2011 | 10:30 p.m. | Pittsburgh Penguins | @ | Los Angeles Kings |
| Nov. 11, 2011 | 7 p.m. | Dallas Stars | @ | Pittsburgh Penguins |
| Nov. 12, 2011 | 7 p.m. | Pittsburgh Penguins | @ | Carolina Hurricanes |
| Nov. 15, 2011 | 7:30 p.m. | Colorado Avalanche | @ | Pittsburgh Penguins |
| Nov. 17, 2011 | 7:30 p.m. | Pittsburgh Penguins | @ | Tampa Bay Lightning |
| Nov. 19, 2011 | 7:30 p.m. | Pittsburgh Penguins | @ | Florida Panthers |
| Nov. 21, 2011 | 7 p.m. | New York Islanders | @ | Pittsburgh Penguins |
| Nov. 23, 2011 | 7 p.m. | St. Louis Blues | @ | Pittsburgh Penguins |
| Nov. 25, 2011 | 7 p.m. | Ottawa Senators | @ | Pittsburgh Penguins |
| Nov. 26, 2011 | 7 p.m. | Pittsburgh Penguins | @ | Montreal Canadiens |
| Nov. 29, 2011 | 7:30 p.m. | Pittsburgh Penguins | @ | New York Rangers |
| Dec. 1, 2011 | 7 p.m. | Pittsburgh Penguins | @ | Washington Capitals |
| Dec. 3, 2011 | 7 p.m. | Pittsburgh Penguins | @ | Carolina Hurricanes |
| Dec. 5, 2011 | 7 p.m. | Boston Bruins | @ | Pittsburgh Penguins |
| Dec. 8, 2011 | 7 p.m. | Pittsburgh Penguins | @ | Philadelphia Flyers |
| Dec. 10, 2011 | 7 p.m. | Pittsburgh Penguins | @ | New York Islanders |
| Dec. 13, 2011 | 7 p.m. | Detroit Red Wings | @ | Pittsburgh Penguins |
| Dec. 16, 2011 | 7:30 p.m. | Pittsburgh Penguins | @ | Ottawa Senators |
| Dec. 17, 2011 | 7 p.m. | Buffalo Sabres | @ | Pittsburgh Penguins |
| Dec. 20, 2011 | 7:30 p.m. | Chicago Blackhawks | @ | Pittsburgh Penguins |
| Dec. 23, 2011 | 8:30 p.m. | Pittsburgh Penguins | @ | Winnipeg Jets |
| Dec. 27, 2011 | 7 p.m. | Carolina Hurricanes | @ | Pittsburgh Penguins |
| Dec. 29, 2011 | 7 p.m. | Philadelphia Flyers | @ | Pittsburgh Penguins |
| Dec. 31, 2011 | 3 p.m. | Pittsburgh Penguins | @ | New Jersey Devils |
| Jan. 6, 2012 | 7 p.m. | New York Rangers | @ | Pittsburgh Penguins |
| Jan. 7, 2012 | 7 p.m. | New Jersey Devils | @ | Pittsburgh Penguins |
| Jan. 10, 2012 | 7 p.m. | Ottawa Senators | @ | Pittsburgh Penguins |
| Jan. 11, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Washington Capitals |
| Jan. 13, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Florida Panthers |
| Jan. 15, 2012 | 1 p.m. | Pittsburgh Penguins | @ | Tampa Bay Lightning |
| Jan. 17, 2012 | 7 p.m. | Carolina Hurricanes | @ | Pittsburgh Penguins |
| Jan. 19, 2012 | 7 p.m. | Pittsburgh Penguins | @ | New York Rangers |
| Jan. 20, 2012 | 7 p.m. | Montreal Canadiens | @ | Pittsburgh Penguins |
| Jan. 22, 2012 | 12:30 p.m. | Washington Capitals | @ | Pittsburgh Penguins |
| Jan. 24, 2012 | 8 p.m. | Pittsburgh Penguins | @ | St. Louis Blues |
| Jan. 31, 2012 | 7 p.m. | Toronto Maple Leafs | @ | Pittsburgh Penguins |
| Feb. 1, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Toronto Maple Leafs |
| Feb. 4, 2012 | 1 p.m. | Pittsburgh Penguins | @ | Boston Bruins |
| Feb. 5, 2012 | 1 p.m. | Pittsburgh Penguins | @ | New Jersey Devils |
| Feb. 7, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Montreal Canadiens |
| Feb. 11, 2012 | 2 p.m. | Winnipeg Jets | @ | Pittsburgh Penguins |
| Feb. 12, 2012 | 7 p.m. | Tampa Bay Lightning | @ | Pittsburgh Penguins |
| Feb. 15, 2012 | 7 p.m. | Anaheim Ducks | @ | Pittsburgh Penguins |
| Feb. 18, 2012 | 1 p.m. | Pittsburgh Penguins | @ | Philadelphia Flyers |
| Feb. 19, 2012 | 12:30 p.m. | Pittsburgh Penguins | @ | Buffalo Sabres |
| Feb. 21, 2012 | 7 p.m. | New York Rangers | @ | Pittsburgh Penguins |
| Feb. 25, 2012 | 1 p.m. | Tampa Bay Lightning | @ | Pittsburgh Penguins |
| Feb. 26, 2012 | 1 p.m. | Columbus Blue Jackets | @ | Pittsburgh Penguins |
| Feb. 29, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Dallas Stars |
| March 3, 2012 | 9 p.m. | Pittsburgh Penguins | @ | Colorado Avalanche |
| March 5, 2012 | 7 p.m. | Phoenix Coyotes | @ | Pittsburgh Penguins |
| March 7, 2012 | 7:30 p.m. | Toronto Maple Leafs | @ | Pittsburgh Penguins |
| March 9, 2012 | 7 p.m. | Florida Panthers | @ | Pittsburgh Penguins |
| March 11, 2012 | 12:30 p.m. | Boston Bruins | @ | Pittsburgh Penguins |
| March 15, 2012 | 7 p.m. | Pittsburgh Penguins | @ | New York Rangers |
| March 17, 2012 | 1 p.m. | Pittsburgh Penguins | @ | New Jersey Devils |
| March 18, 2012 | 12:30 p.m. | Pittsburgh Penguins | @ | Philadelphia Flyers |
| March 20, 2012 | 7 p.m. | Winnipeg Jets | @ | Pittsburgh Penguins |
| March 22, 2012 | 7 p.m. | Nashville Predators | @ | Pittsburgh Penguins |
| March 24, 2012 | 7 p.m. | Pittsburgh Penguins | @ | Ottawa Senators |
| March 25, 2012 | 7 p.m. | New Jersey Devils | @ | Pittsburgh Penguins |
| March 27, 2012 | 7 p.m. | New York Islanders | @ | Pittsburgh Penguins |
| March 29, 2012 | 7 p.m. | Pittsburgh Penguins | @ | New York Islanders |
| March 30, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Buffalo Sabres |
| April 1, 2012 | 12:30 p.m. | Philadelphia Flyers | @ | Pittsburgh Penguins |
| April 3, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Boston Bruins |
| April 5, 2012 | 7 p.m. | New York Rangers | @ | Pittsburgh Penguins |
| April 7, 2012 | 4 p.m. | Philadelphia Flyers | @ | Pittsburgh Penguins |
| April 11, 2012 | 7:30 p.m. | Philadelphia Flyers | @ | Pittsburgh Penguins |
| April 13, 2012 | 7:30 p.m. | Philadelphia Flyers | @ | Pittsburgh Penguins |
| April 15, 2012 | 3 p.m. | Pittsburgh Penguins | @ | Philadelphia Flyers |
| April 18, 2012 | 7:30 p.m. | Pittsburgh Penguins | @ | Philadelphia Flyers |
| April 20, 2012 | 7:30 p.m. | Philadelphia Flyers | @ | Pittsburgh Penguins |
| April 22, 2012 | noon | Pittsburgh Penguins | @ | Philadelphia Flyers |
