| Date | Time | Away Team | Home Team | |
|---|---|---|---|---|
| Oct. 7, 2011 | 7 p.m. | Ottawa Senators | @ | Detroit Red Wings |
| Oct. 8, 2011 | 7 p.m. | Ottawa Senators | @ | Toronto Maple Leafs |
| Oct. 11, 2011 | 7:30 p.m. | Minnesota Wild | @ | Ottawa Senators |
| Oct. 13, 2011 | 7:30 p.m. | Colorado Avalanche | @ | Ottawa Senators |
| Oct. 15, 2011 | 7 p.m. | Ottawa Senators | @ | Washington Capitals |
| Oct. 18, 2011 | 7:30 p.m. | Philadelphia Flyers | @ | Ottawa Senators |
| Oct. 20, 2011 | 7:30 p.m. | Winnipeg Jets | @ | Ottawa Senators |
| Oct. 22, 2011 | 7 p.m. | Columbus Blue Jackets | @ | Ottawa Senators |
| Oct. 25, 2011 | 7 p.m. | Ottawa Senators | @ | Carolina Hurricanes |
| Oct. 27, 2011 | 7:30 p.m. | Florida Panthers | @ | Ottawa Senators |
| Oct. 29, 2011 | 3 p.m. | Ottawa Senators | @ | New York Rangers |
| Oct. 30, 2011 | 7:30 p.m. | Toronto Maple Leafs | @ | Ottawa Senators |
| Nov. 1, 2011 | 7 p.m. | Ottawa Senators | @ | Boston Bruins |
| Nov. 4, 2011 | 7:30 p.m. | Montreal Canadiens | @ | Ottawa Senators |
| Nov. 5, 2011 | 7 p.m. | Buffalo Sabres | @ | Ottawa Senators |
| Nov. 9, 2011 | 7:30 p.m. | New York Rangers | @ | Ottawa Senators |
| Nov. 11, 2011 | 7:30 p.m. | Ottawa Senators | @ | Buffalo Sabres |
| Nov. 12, 2011 | 7 p.m. | Ottawa Senators | @ | Toronto Maple Leafs |
| Nov. 15, 2011 | 9 p.m. | Ottawa Senators | @ | Calgary Flames |
| Nov. 17, 2011 | 9:30 p.m. | Ottawa Senators | @ | Edmonton Oilers |
| Nov. 20, 2011 | 9 p.m. | Ottawa Senators | @ | Vancouver Canucks |
| Nov. 25, 2011 | 7 p.m. | Ottawa Senators | @ | Pittsburgh Penguins |
| Nov. 27, 2011 | 5 p.m. | Carolina Hurricanes | @ | Ottawa Senators |
| Nov. 29, 2011 | 8:30 p.m. | Ottawa Senators | @ | Winnipeg Jets |
| Dec. 1, 2011 | 8:30 p.m. | Ottawa Senators | @ | Dallas Stars |
| Dec. 3, 2011 | 7 p.m. | Ottawa Senators | @ | Washington Capitals |
| Dec. 5, 2011 | 7:30 p.m. | Tampa Bay Lightning | @ | Ottawa Senators |
| Dec. 7, 2011 | 7 p.m. | Washington Capitals | @ | Ottawa Senators |
| Dec. 8, 2011 | 7 p.m. | Ottawa Senators | @ | New Jersey Devils |
| Dec. 10, 2011 | 7 p.m. | Vancouver Canucks | @ | Ottawa Senators |
| Dec. 13, 2011 | 7 p.m. | Ottawa Senators | @ | Buffalo Sabres |
| Dec. 14, 2011 | 7:30 p.m. | Boston Bruins | @ | Ottawa Senators |
| Dec. 16, 2011 | 7:30 p.m. | Pittsburgh Penguins | @ | Ottawa Senators |
| Dec. 20, 2011 | 7:30 p.m. | Buffalo Sabres | @ | Ottawa Senators |
| Dec. 22, 2011 | 7:30 p.m. | Florida Panthers | @ | Ottawa Senators |
| Dec. 23, 2011 | 7 p.m. | Ottawa Senators | @ | Carolina Hurricanes |
| Dec. 27, 2011 | 7:30 p.m. | Montreal Canadiens | @ | Ottawa Senators |
| Dec. 30, 2011 | 7:30 p.m. | Calgary Flames | @ | Ottawa Senators |
| Dec. 31, 2011 | 7 p.m. | Ottawa Senators | @ | Buffalo Sabres |
| Jan. 2, 2012 | 7:30 p.m. | New Jersey Devils | @ | Ottawa Senators |
| Jan. 5, 2012 | 7:30 p.m. | Tampa Bay Lightning | @ | Ottawa Senators |
| Jan. 7, 2012 | 1 p.m. | Ottawa Senators | @ | Philadelphia Flyers |
| Jan. 8, 2012 | 5 p.m. | Philadelphia Flyers | @ | Ottawa Senators |
| Jan. 10, 2012 | 7 p.m. | Ottawa Senators | @ | Pittsburgh Penguins |
| Jan. 12, 2012 | 7 p.m. | Ottawa Senators | @ | New York Rangers |
| Jan. 14, 2012 | 7 p.m. | Ottawa Senators | @ | Montreal Canadiens |
| Jan. 16, 2012 | 7:30 p.m. | Winnipeg Jets | @ | Ottawa Senators |
| Jan. 17, 2012 | 7 p.m. | Ottawa Senators | @ | Toronto Maple Leafs |
| Jan. 19, 2012 | 10:30 p.m. | Ottawa Senators | @ | San Jose Sharks |
| Jan. 21, 2012 | 4 p.m. | Ottawa Senators | @ | Anaheim Ducks |
| Jan. 23, 2012 | 10:30 p.m. | Ottawa Senators | @ | Los Angeles Kings |
| Jan. 24, 2012 | 9 p.m. | Ottawa Senators | @ | Phoenix Coyotes |
| Jan. 31, 2012 | 7 p.m. | Ottawa Senators | @ | Boston Bruins |
| Feb. 3, 2012 | 7:30 p.m. | New York Islanders | @ | Ottawa Senators |
| Feb. 4, 2012 | 7 p.m. | Toronto Maple Leafs | @ | Ottawa Senators |
| Feb. 7, 2012 | 7:30 p.m. | St. Louis Blues | @ | Ottawa Senators |
| Feb. 9, 2012 | 7:30 p.m. | Nashville Predators | @ | Ottawa Senators |
| Feb. 11, 2012 | 2 p.m. | Edmonton Oilers | @ | Ottawa Senators |
| Feb. 14, 2012 | 7 p.m. | Ottawa Senators | @ | Tampa Bay Lightning |
| Feb. 15, 2012 | 7:30 p.m. | Ottawa Senators | @ | Florida Panthers |
| Feb. 20, 2012 | 1 p.m. | Ottawa Senators | @ | New York Islanders |
| Feb. 22, 2012 | 7 p.m. | Washington Capitals | @ | Ottawa Senators |
| Feb. 25, 2012 | 7 p.m. | Boston Bruins | @ | Ottawa Senators |
| Feb. 26, 2012 | 5 p.m. | New York Islanders | @ | Ottawa Senators |
| Feb. 28, 2012 | 7 p.m. | Ottawa Senators | @ | Boston Bruins |
| March 2, 2012 | 7 p.m. | Chicago Blackhawks | @ | Ottawa Senators |
| March 4, 2012 | 6 p.m. | Ottawa Senators | @ | Florida Panthers |
| March 6, 2012 | 7:30 p.m. | Ottawa Senators | @ | Tampa Bay Lightning |
| March 8, 2012 | 7:30 p.m. | New York Rangers | @ | Ottawa Senators |
| March 10, 2012 | 7 p.m. | Buffalo Sabres | @ | Ottawa Senators |
| March 14, 2012 | 7:30 p.m. | Ottawa Senators | @ | Montreal Canadiens |
| March 16, 2012 | 7 p.m. | Montreal Canadiens | @ | Ottawa Senators |
| March 17, 2012 | 7 p.m. | Toronto Maple Leafs | @ | Ottawa Senators |
| March 20, 2012 | 7:30 p.m. | New Jersey Devils | @ | Ottawa Senators |
| March 23, 2012 | 7:30 p.m. | Ottawa Senators | @ | Montreal Canadiens |
| March 24, 2012 | 7 p.m. | Pittsburgh Penguins | @ | Ottawa Senators |
| March 26, 2012 | 8:30 p.m. | Ottawa Senators | @ | Winnipeg Jets |
| March 31, 2012 | 1 p.m. | Ottawa Senators | @ | Philadelphia Flyers |
| April 1, 2012 | 3 p.m. | Ottawa Senators | @ | New York Islanders |
| April 3, 2012 | 7:30 p.m. | Carolina Hurricanes | @ | Ottawa Senators |
| April 5, 2012 | 7:30 p.m. | Boston Bruins | @ | Ottawa Senators |
| April 7, 2012 | 3 p.m. | Ottawa Senators | @ | New Jersey Devils |
| April 12, 2012 | 7 p.m. | Ottawa Senators | @ | New York Rangers |
| April 14, 2012 | 7 p.m. | Ottawa Senators | @ | New York Rangers |
| April 16, 2012 | 7:30 p.m. | New York Rangers | @ | Ottawa Senators |
| April 18, 2012 | 7:30 p.m. | New York Rangers | @ | Ottawa Senators |
| April 21, 2012 | 7 p.m. | Ottawa Senators | @ | New York Rangers |
| April 23, 2012 | 7 p.m. | New York Rangers | @ | Ottawa Senators |
| April 26, 2012 | 7 p.m. | Ottawa Senators | @ | New York Rangers |
